The effectiveness of this objectified ingredient has been demonstrated in two different clinical studies.
The first study conducted in 2009 was carried out with 70 adults experiencing stress and fatigue on a daily basis. A first group was supplemented with 10 mg of concentrated EXTRAMEL Melon juice (Melon SOD) per day for 4 weeks, while the second group took a placebo.
Following these 4 weeks, the treated group showed a significant improvement in the signs and symptoms of perceived stress and fatigue related to physical performance (sleep disturbances - 38%), cognitive (concentration, weariness - 22%) or behavioral (irritability - 30%) compared to placebo. Study participants also reported improved quality of life (+42%).
The second study carried out in 2014 was conducted among 61 adults with psychological stress and physical and mental fatigue. Similarly, the treated group received one capsule daily containing 10 mg of EXTRAMEL (Melon SOD), while the control group received a placebo.*
At the end of the study, people in the treated group showed a significant decrease in perceived stress (-7.2%) as well as physical (-9%) and mental (-20.8%) fatigue . They also reported an improvement in quality of life (+7%).**
*Study Milesi, M.-A., Lacan, D., Brosse, H., Desor, D. & Notin, C. Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel®) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial. Nutrition Journal 8, 40 (2009).
**Study Carillon, J., Notin, C., Schmitt, K., Simoneau, G. & Lacan, D. Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 6, 2348–2359 (2014).