The flavanols present in grape seed extract improve collagen synthesis by increasing the level of collagen precursors in fibroblasts.
Similarly, vitamin C plays a role in the synthesis of type I collagen (predominant in the skin) and type IV (component of the cellular basement membrane).
Decreased superoxide dismutase (SOD) is associated with the breakdown of collagen, leading to loss of elasticity and atrophy of the skin. SOD, mainly present in the extracellular matrix, is associated with type I collagen and protects collagen from oxidation, thus preventing premature aging of cells. In addition, flavanols provide collagen stability by forming bonds with collagen fibers, and they are also able to inhibit collagenase activity.
W. SkinAx study, “CUSTOMER TECHNICAL SUPPORT”.