In 2021, Lopresti et al. conducted a randomized double-blind study with a control group receiving a placebo to evaluate the effects of Saffron extract AFFRON® on sleep and stress. Over a period of 28 days, 120 adults dissatisfied with their sleep took part in this study.
The participants were divided into three groups. The first group consumed 14 mg of AFFRON® extract one hour before bedtime, the second group received 28 mg of AFFRON® extract, and the third group received a placebo.
The results showed that supplementation of Saffron with AFFRON® resulted in an increase in endogenous melatonin at bedtime for both extract concentrations. The effects on sleep were similar for the first two groups, with a significant improvement in sleep quality (+22%) and mood upon awakening, as well as a decrease in insomnia problems , compared to the group that received the placebo.
In summary, this study suggests that supplementation with Saffron extract AFFRON® has beneficial effects on sleep and mental well-being, improving sleep quality and reducing insomnia problems in people who are dissatisfied with their sleep. .
Study. Lopresti, AL, Smith, SJ & Drummond, PD An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled , multi-dose study. Sleep Medicine 86, 7–18 (2021).